3-(7-Fluoro-2-quinolinylmethoxy)aniline → 4-[3-(7-Fluoro-2-quinolinylmethoxy)phenylamino]-2,2-dibutyl-4-oxobutanoic acid

HRID 1721190Notes

Reaction equation

HRID 1721190 reaction equation
[CH2:1]([C:5]1([CH2:12][CH2:13][CH2:14][CH3:15])[CH2:10][C:9](=[O:11])[O:8][C:6]1=[O:7])[CH2:2][CH2:3][CH3:4].[F:16][C:17]1[CH:26]=[C:25]2[C:20]([CH:21]=[CH:22][C:23]([CH2:27][O:28][C:29]3[CH:30]=[C:31]([CH:33]=[CH:34][CH:35]=3)[NH2:32])=[N:24]2)=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:26]=[C:25]2[C:20]([CH:21]=[CH:22][C:23]([CH2:27][O:28][C:29]3[CH:30]=[C:31]([NH:32][C:9](=[O:11])[CH2:10][C:5]([CH2:12][CH2:13][CH2:14][CH3:15])([CH2:1][CH2:2][CH2:3][CH3:4])[C:6]([OH:8])=[O:7])[CH:33]=[CH:34][CH:35]=3)=[N:24]2)=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 224168723-(7-Fluoro-2-quinolinylmethoxy)anilineHCID 542008372,2-Dibutylsuccinic acid anhydride

Product 1

HCID 224168554-[3-(7-Fluoro-2-quinolinylmethoxy)phenylamino]-2,2-dibutyl-4-oxobutanoic acid

Procedure

The title compound is prepared analogously to the compound described in Example 20 from 2,2-dibutylsuccinic acid anhydride (prepared analogously to the instructions of H. Le Moal et al. Bull. Soc. Chim. 1964, 579 and 828) and 3-(7-fluoro-2-quinolinylmethoxy)aniline; beige crystals of m.p. 156°-157°.

Workup

  1. customprepared analogously to the instructions of H

Sources & evidence

ORD record
ord-90d39f44efa84983b51883856693a253
Source dataset
uspto-grants-1996_04
Patent number
US05508408

Reaction notes

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