2-(2-(Dimethylamino)phenyl)acetic acid → HCID 22856112, compound

HRID 1721206Notes

Reaction equation

HRID 1721206 reaction equation
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=O.Cl.[C:15]1([C:21]2([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[CH2:29][CH2:28][C@H:27]([F:30])[C@@H:26]3[C@H:22]2[CH2:23][NH:24][CH2:25]3)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH3:13][N:2]([CH3:1])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([N:24]1[CH2:23][C@@H:22]2[C@@H:26]([C@@H:27]([F:30])[CH2:28][CH2:29][C:21]2([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH2:25]1)=[O:12]

Participants

3

Reactant 2

HCID 204661092-(2-(Dimethylamino)phenyl)acetic acidHCID 67809331HCID 67809331, compound

Product 1

HCID 22856112HCID 22856112, compoundYield 27%

Procedure

By carrying out the procedure as in Example 9 below, using 0.16 g of 2-dimethylaminophenylacetic acid and 0.30 g of (3aR, 7S, 7aR)-4,4-diphenyl-7-fluoroperhydroisoindole hydrochloride, 0.11 g of (3aR, 7S, 7aR)-2-[(2-dimethylaminophenyl)acetyl]4,4-diphenyl-7-fluoroperhydroisoindole is obtained in the form of a white meringue.

Sources & evidence

ORD record
ord-8ba50deaaff14089b9f62f3810a965a8
Source dataset
uspto-grants-1996_04
Patent number
US05508433

Reaction notes

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