2-(2-(Dimethylamino)phenyl)acetic acid → HCID 22856090, compound

HRID 1721214Notes

Reaction equation

HRID 1721214 reaction equation
[CH3:1][N:2]([CH3:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=O.Cl.[C:15]1([C:21]2([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)[C@H:29]3[C@H:25]([CH2:26][NH:27][CH2:28]3)[C@H:24]([OH:30])[CH2:23][CH2:22]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH3:13][N:2]([CH3:1])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([N:27]1[CH2:26][C@H:25]2[C@H:29]([C:21]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[CH2:22][CH2:23][C@H:24]2[OH:30])[CH2:28]1)=[O:12]

Participants

3

Reactant 2

HCID 204661092-(2-(Dimethylamino)phenyl)acetic acidHCID 22856093HCID 22856093, compound

Product 1

HCID 22856090HCID 22856090, compoundYield 31.8%

Procedure

By carrying out the procedure according to that described in the Example of use 9, using 0.26 g of 2-dimethylaminophenylacetic acid and 0.50 g of (3aR,4R,7aR)-7,7-diphenyl-4-perhydroisoindolol hydrochloride, 0.21 g of (3aR,4R,7aR)-2-[(2dimethylaminophenyl)acetyl]-7,7-diphenyl-4-perhydroisoindolol is obtained in the form of a white solid; melting point 204° C., [α]20D =-212° (c =0.5, methanol).

Sources & evidence

ORD record
ord-717edc7c7eaf4d4c9a7e79047e0841dd
Source dataset
uspto-grants-1996_04
Patent number
US05508433

Reaction notes

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