Piperazine → HCID 22414342, compound

Participants

Reaction Steps

A solution containing 2.0 g (9.17 mmoles) of 2,4-dichloro-6-pyrrolidinopyrimidine and 3.95 (45.9 mmoles) of piperazine in ethanol is boiled under reflux for 1 hour and then evaporated. The evaporation residue is distributed between 100 ml of chloroform and 100 ml of 1% sodium hydroxide solution. After separation the organic phase is washed twice with 50 ml of water each, then dried and evaporated. The evaporation residue is subjected to chromatography on a silica gel column. By using a 9:1 mixture of chloroform/methanol as eluent and recrystallizing the obtained product from hexane, the title compound is obtained in a yield of 1.66 g (67.6%), m.p.: 77°-92° C.

Provenance & Evidence