反应详情

A solution containing 26.0 g (87.25 mmoles) of 4,6-dichloro-2-(1-adamantylamino)pyrimidine and 39.5 g (261.6 mmoles) of 1-aminoadamantane in 200 ml of n-butanol is boiled under reflux for 75 hours, then evaporated. The evaporation residue is suspended in 400 ml of ether, the suspension is filtered off and, after drying, the product filtered off is purified by chromatography on a silica gel column. By using chloroform as eluent and recrystallizing the obtained product from ether the title compound is obtained in a yield of 23.94 g (66.44%), m.p.: 232°-236° C.

1. temperatureunder reflux for 75 hours
2. customevaporated
3. filtrationthe suspension is filtered off
4. customafter drying
5. filtrationthe product filtered off
6. customis purified by chromatography on a silica gel column
7. customrecrystallizing the obtained product from ether the title compound
8. customis obtained in a yield of 23.94 g (66.44%), m.p.: 232°-236° C.