CID 406 → Diethyl ((thiophen-2-yl)methyl)phosphonate

HRID 1721320Notes

Reaction equation

P(=O)([O-])[O-].[S:5]1[CH:9]=[CH:8][C:7](CP(=O)(OCC)OCC)=[CH:6]1.O1C=CC=C1[CH2:24][P:25](=[O:32])([O:29][CH2:30][CH3:31])[O:26][CH2:27][CH3:28].FC1C=CC=CC=1CP(=O)(OCC)OCC.COC1C=C(C=C(OC)C=1OC)CP(=O)(OCC)OCC>>[S:5]1[CH:6]=[CH:7][CH:8]=[C:9]1[CH2:24][P:25](=[O:32])([O:29][CH2:30][CH3:31])[O:26][CH2:27][CH3:28]

Participants

Reactant 5

HCID 406CID 406

HCID 16263682-(Diethoxyphosphorylmethyl)furan

HCID 10018756Diethyl 3,4,5-trimethoxybenzylphosphonate

HCID 11117975Diethyl [(thiophen-3-yl)methyl]phosphonate

HCID 11207329Diethyl 2-Fluorobenzylphosphonate

Product 1

HCID 4185897Diethyl ((thiophen-2-yl)methyl)phosphonate

Procedure

The following phosphonate reagents were also prepared by the above-described method: diethyl 3-thienylmethylphosphonate. diethyl 2-furanylmethylphosphonate, diethyl 2-fluorobenzylphosphonate, and diethyl 3,4,5-trimethoxybenzylphos-phonate.

Sources & evidence

ORD record: ord-3d2017de48b34fd19c2881b81003bd17
Source dataset: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05510351

Reaction notes

Loading…