Sodium Carbonate → HCID 22414643, compound

HRID 1721352Notes

Reaction equation

HRID 1721352 reaction equation
B(Br)(Br)Br.C[O:6][C:7]1[CH:8]=[CH:9][C:10]2[S:14][CH:13]=[C:12]([CH:15]=[O:16])[C:11]=2[CH:17]=1.C([O-])([O-])=O.[Na+].[Na+]>C(Cl)Cl>[OH:6][C:7]1[CH:8]=[CH:9][C:10]2[S:14][CH:13]=[C:12]([CH:15]=[O:16])[C:11]=2[CH:17]=1

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 25134Boron tribromideHCID 152079765-Methoxy-1-benzothiophene-3-carbaldehyde

Product 1

HCID 22414643HCID 22414643, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of BBr3 (0.07 mol) in 15 ml CH2Cl2 is added at 0° to a solution of 0.014 mol 5-methoxy-benzothiophene-3-carboxaldehyde in 80 ml CH2Cl2. After 4 hours 2 N Na2CO3 is added until pH=7. The organic solvent is evaporated and the suspension is filtered. The solid is washed with water to yield crude title compound which is recrystallized from CH3OH/H2O. M.p.=200°.

Workup

  1. customThe organic solvent is evaporated
  2. filtrationthe suspension is filtered
  3. washThe solid is washed with water

Sources & evidence

ORD record
ord-2f840e9dc0674a0898441fc3e30816cc
Source dataset
uspto-grants-1996_04
Patent number
US05510353

Reaction notes

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