Water → 1-(4-Nitrophenyl)-1H-1,2,4-triazole

Participants

Reaction Steps

1,2,4-Triazole sodium derivative (90%) (17.74 g, 0.18 mol) and 1-fiuoro-4-nitrobenzene (25 g, 0.18 mol), in DMF, (150 ml) was stirred at room temperature for 4 days. Water (300 ml) and ethyl acetate (500 ml) were added and the mixture extracted. The organic layer was separated, washed with water (3×300 ml), dried (MgSO4) and evaporated to give the desired product (24.8 g); δ (360 MHz, CDCl3)7.92 (2H, d, J=9.1 Hz, Ar--H), 8.17 (1H, s, Ar--H), 8.40 (2H, d, J=9.1 Hz, Ar--H), 8.48 (1H, s, Ar--H).

Provenance & Evidence