1,2-Dichloroethane → HCID 86749455, compound

Participants

Reaction Steps

To a stirred solution of 100 mg (0.31 mmol) of trans-4-(t-Butoxycarbonyl)aminocyclohexylmethyl L-proline amide, 70 mg (0.31 mmol) of 3,3 diphenylpropionic acid, 46 mg (0.34 mmol) of HOBT, and 34 mg (0.34 mmol) of triethylamine in 2 ml of anh. DMF under a nitrogen atmosphere was added 65 mg (0.34 mmol) of EDC. The resulting solution was stirred at room temp. for 18 h. The reaction was diluted with 2× its' volume of aq. 10% citric acid solution, and the mixture extracted 2× with EtOAc. The combined EtOAc extracts were washed with water and brine, and were dried over anh. MgSO4. Filtration and concentration gave crude product as a yellow oil. The product was purified via column chromatography over silica gel with 3:2 EtOAc/CHCL3 to give 109 mg (64%) of product as a clear glass.

Provenance & Evidence