Hydrochloric Acid → HCID 22415600, compound

Participants

Reaction Conditions

Reaction Steps

9.8 g of (dibenzofuran-3-yl)-diphenyl-phosphine oxide in 100 ml of THF are admixed with 13.3 ml of a 2M solution of lithium diisopropylamide in THF/n-heptane and stirred for a further 10 minutes at -78° C. A solution of 7.9 g of iodine in 30 ml of THF is added at -76° C. Subsequently the mixture is hydrolyzed with 2N HCl, ethyl acetate is added, the solution is washed with sodium thiosulphate solution, water and saturated NaCl solution, dried with MgSO4 and concentrated. 12.7 g (98% of theoretical) of crude product remain.

Provenance & Evidence