反应详情

In a flask was placed 1.0 g (12.2 mmol) 1-methylimidazole. Then, 5.1 ml (12.8 mmol) n-butyllithium was added dropwise and the mixture was stirred for 30 minutes. Then, 2.7 g (12.2 mmol) 3-trifluoromethoxybenzoyl chloride was added dropwise. The contents were mixed for 2 hours at -78° C., then allowed to warm to room temperature for an additional 2 hours. The mixture was quenched with water. The product was extracted with ether, dried and purified by flash chromatography (5-10% ethyl acetate/hexanes, silica gel) and was identified as the desired product by spectroscopic analyses.

1. customIn a flask was placed
2. additionThe contents were mixed for 2 hours at -78° C.
3. customThe mixture was quenched with water
4. extractionThe product was extracted with ether
5. customdried
6. custompurified by flash chromatography (5-10% ethyl acetate/hexanes, silica gel)