2,5-Dibromopyridine → HCID 53721361, compound

HRID 1721585Notes

Reaction equation

HRID 1721585 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][N:3]=1.[CH2:9]([O:16][C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][CH:18]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[Br:8][C:5]1[CH:6]=[CH:7][C:2]([C:20]2[CH:21]=[CH:22][C:17]([O:16][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)=[CH:18][CH:19]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 693532,5-DibromopyridineHCID 27343144-Benzyloxy-phenylboronic acid

Product 1

HCID 53721361HCID 53721361, compoundYield 147.6%

Procedure

In accordance with scheme C-I, 10 g of 2,5-dibromopyridine and 19.24 g of 4-benzyloxyphenylboronic acid are coupled analogously to Example 4a to give 21.2 g (73.9%) of 5-bromo-2-(4-benzyloxyphenyl)pyridine.

Sources & evidence

ORD record
ord-cae6ae11b5494b05a57fc8176dfaf4e2
Source dataset
uspto-grants-1996_04
Patent number
US05512207

Reaction notes

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