HCID 22413374, compound → HCID 22413368, compound

Participants

Reaction Steps

0.5 g (0.0016 mol) 1-(benzofuran-7-yl)-6,7-dihydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine was dissolved in a mixture of 25 ml ethanol and 2 ml acetic acid. 0.2 g catalyst (10% Pd/C) was added and the mixture was submitted to hydrogenation in a Parr apparatus at a pressure of 50 psi. After 24 h the catalyst was filtered off and the solution was concentrated in vacuo. The residue was redissolved in dichloromethane, the solution was washed subsequently with NaHCO3-solution, water and brine. Evaporation in vacuo gave 1-(2,3-dihydrobenzofuran-7-yl)-6,7-dihydroxy-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine as an offwhite foam.

Provenance & Evidence