N-bromobutanimide → HCID 15308026, compound

HRID 1721613Notes

Reaction equation

HRID 1721613 reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([O:14][C:15]([N:17]2[CH2:22][CH2:21][CH:20]([CH2:23]O)[CH2:19][CH2:18]2)=[O:16])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:25]N1C(=O)CCC1=O>C1C=CC=CC=1>[Br:25][CH2:23][CH:20]1[CH2:21][CH2:22][N:17]([C:15]([O:14][C:11]2[CH:12]=[CH:13][C:8]([O:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:9][CH:10]=2)=[O:16])[CH2:18][CH2:19]1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 15308024HCID 15308024, compound

Product 1

HCID 15308026HCID 15308026, compoundYield 210.1%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

The hydroxymethyl derivative produced in Example 30 (5.0 g, 15 mmol) and wiphenylphosphine (4.0 g, 15 mmol) were dissolved in 100 ml of benzene and the resulting solution put under a nitrogen atmosphere. N-Bromosuccinimide (2.7 g, 15 mmol) was added in portions to the above solution and the reaction stirred at room temperature overnight. The solvent was removed under reduced pressure to give 12.3 g of a brown oil. Purification of this oil by chromatography on 600 g of silica gel (230-400 mesh) using ethyl acetate-hexane as the eluent gave 4.52 g of a white solid. Recrystallization of this solid from diisopropyl ether gave the title compound as a white crystalline solid (4.12 g, 68%), mp 76°-78° C.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-535ae65c28a843c59fa3e8a6861fb3ad
Source dataset
uspto-grants-1996_04
Patent number
US05512565

Reaction notes

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