HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,6-Dichloro-3-oxoindan-1-carbonyl chloride → 4-(5,6-Dichloro-3-oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)morpholine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,6-Dichloro-3-oxoindan-1-carbonyl chloride | HCID 15132407 | — |
| Reactant | 3-(Pyrrolidin-1-ylmethyl)morpholine | HCID 18915061 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 4-(5,6-Dichloro-3-oxoindan-1-carbonyl)-3-(pyrrolidin-1-ylmethyl)morpholine hydrochloride | HCID 18915068 | 80.2% |
Reaction Steps
The procedure described in Example 24 was repeated, but using 0.88 g of 3-(pyrrolidin-1-ylmethyl)morpholine, 2.0 ml of triethylamine and 1.0 g of 5,6-dichloro-3-oxo-indan-1-carbonyl chloride, to afford 0.66 g of the title compound, melting at 250°-257° C. (dec.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05512567 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-72470e06c4e54f6b800e2cd2bc1cce85 |
| Source note | uspto-grants-1996_04 |