Pyridine → 1H-1-Benzazepine

HRID 1721668Notes

Reaction equation

[C:1](Cl)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:10]1C=C[CH:13]=[CH:12][CH:11]=1>>[NH:10]1[C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[CH:1]=[CH:13][CH:12]=[CH:11]1

Participants

Reactant 2

HCID 1049Pyridine

HCID 7412Benzoyl chloride

Product 1

HCID 155596581H-1-Benzazepine

Procedure

As described for Example 1, 5 mmol of 4- (2,4-dichlorobenzoyl)amino!benzoyl chloride is reacted with 5 mmol of 5,6-dihydro-7H-pyrimido 5,4-d! 1benzazepine in pyridine to give the product as a solid.

Sources & evidence

ORD record: ord-2558f55ad07a4219b06342c2982bc50f
Source dataset: uspto-grants-1996_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05512563

Reaction notes

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