Thiourea → HCID 22413713, compound

Participants

Reaction Steps

A suspension of 2-acetamidomethyl-5-chloroacetyl-3-methylfuran (24.8 g) and thiourea (8.2 g) in ethanol (250 ml) was stirred at room temperature for 2 hours. The resulting precipitate was collected by filtration and then dissolved in water (200 ml). The mixture was alkalized with an aqueous potassium carbonate solution. The resulting precipitate was collected by filtration to afford 4-(5-acetylaminomethyl-4-methylfuran-2-yl)-2-aminothiazole (16.7 g).

Provenance & Evidence