反应详情

A mixture of 3,4-dihydro-6-(2-quinolylmethoxy)-1(2H)-naphthalenone (1.82 g, 6 mmol), prepared as in step 2, and sodium borohydride (230 mg, 6 mmol) in ethanol (15 mL) was refluxed for 30 minutes. The reaction was allowed to warm to ambient temperature and was then quenched with saturated NH4Cl. Extraction with ethyl acetate and purification on a silica gel column eluting with 9:1 CH2Cl2 -ethyl acetate afforded 1.79 g of 1,2,3,4-tetrahydro-6-(2-quinolylmethoxy)-1-naphthalenol.

1. temperaturewas refluxed for 30 minutes
2. customwas then quenched with saturated NH4Cl
3. extractionExtraction
4. customwith ethyl acetate and purification on a silica gel column
5. washeluting with 9:1 CH2Cl2 -ethyl acetate