Methanol → HCID 178498304, compound

Participants

Reaction Steps

To a suspension of 6-hydroxynicotinic acid (20.0 g, 0.144 mol) in methanol as (350 ml) at room temperature was added concentatrated sulfuric acid (9.98 ml, 0.179 mol) and the mixture was refluxed with vigorous stirring for 16 hours. Much of the organic solvent was removed in vacuo. The remaining residue was neutralized with saturated aqueous NaHCO3, and the product was extracted from the aqueous phase with ethyl acetate. The organic layer was dried over MgSO4 and concentrated in vacuo to give 11.50 g of 6-hydroxynicotinic acid methyl ester as a creamish powder.

Provenance & Evidence