HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyldimethylsilyl chloride → (2S,4R)-4-(tert-butyldimethylsilyloxy)-4-(3-bromophenyl)-2-methyltetrahydropyran
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyldimethylsilyl chloride | HCID 28928 | — |
| Reactant | (2S,4R)-4-hydroxy-4-(3-bromophenyl)-2-methyltetrahydropyran | HCID 54527261 | — |
| Product | (2S,4R)-4-(tert-butyldimethylsilyloxy)-4-(3-bromophenyl)-2-methyltetrahydropyran | HCID 54104922 | 78% |
Reaction Steps
Using an analogous procedure to that described in the portion of Example 18 which is concerned with the preparation of starting materials, the 4-(3-bromophenyl)-2-methyltetrahydropyran so obtained was reacted with tert-butyldimethylsilyl chloride to give (2S,4R)-4-(tert-butyldimethylsilyloxy)-4-(3-bromophenyl)-2-methyltetrahydropyran in 78% yield as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05512594 |
| Source dataset | uspto-grants-1996_04 |
| ORD ID | ord-d33033058b09445aafc21a85caae4cbe |
| Source note | uspto-grants-1996_04 |