Methyl 1-methyl-4,5-dihydro-1H-imidazole-4-carboxylate → METHYL 1-METHYL-1H-IMIDAZOLE-4-CARBOXYLATE

Participants

Reaction Steps

19.0 g of manganese dioxide was added to a stirred solution of 4.7 g of 38D in ethanol-free, chloroform and the mixture was stirred overnight at room temperature. The mixture was heated at reflux for 1 hour, cooled, 9.5 g of manganese dioxide was added; the mixture was stirred at room temperature for 2 hours and at reflux for 30 minutes. The mixture was cooled and filtered and the filtrate was stripped of solvent to give methyl 1-methylimidazole-4-carboxylate (38E), as a yellow solid, m.p.: 72.5°-81° C.

Provenance & Evidence