反应详情

3.2 g. (7.5 mmole) of the compound of Example 13 are heated under reflux for 5 hours with 50 ml. 5% aqueous sodium hydroxide solution and 40 ml. ethanol. The reaction mixture is evaporated and the residue is taken up in water, washed with diethyl ether and the aqueous phase is adjusted to pH 6, extracted with dichloromethane, dried and evaporated. After trituration of the residue with diethyl ether, there are obtained 2.2 g. of the title compound (71% of theory); m.p. 100°-102° C.

1. temperatureunder reflux for 5 hours with 50 ml
2. customThe reaction mixture is evaporated
3. washwashed with diethyl ether
4. extractionextracted with dichloromethane
5. customdried
6. customevaporated
7. customAfter trituration of the residue with diethyl ether, there are obtained 2.2 g