Methyl Isocyanate → HCID 14649993, compound

Participants

Reaction Steps

To a solution of 2.22 g of 4-phenyl-4-(3-trifluoromethylphenoxy)piperidine in 50 ml of benzene was added 0.40 g of methyl isocyanate. The reaction mixture was stirred at room temperature for 2.5 hours. Evaporation of the volatile afforded an oil which was purified by means of high pressure liquid chromatography (silica gel; elution with 50% ethyl acetate/dichloromethane) to yield 2.04 g (77%) of 1-(N-methylamino)carbonyl-4-phenyl-4-(3-trifluoromethylphenoxy)piperidine, m.p. 124°-127° C.

Provenance & Evidence