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Chloroacetyl chloride → 1-(2-Chloroacetyl)-4-(2,3,4,5,6-pentafluorophenoxy)-4-phenylpiperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetyl chloride | HCID 6577 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-(2,3,4,5,6-Pentafluorophenoxy)-4-phenylpiperidine | HCID 14649978 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-(2-Chloroacetyl)-4-(2,3,4,5,6-pentafluorophenoxy)-4-phenylpiperidine | HCID 14649982 | — |
反応手順
A chilled solution of 4.0 g of 4-(2,3,4,5,6-pentafluorophenoxy)-4-phenylpiperidine and 2.4 ml of triethylamine in 50 ml of dichloromethane was treated with a solution of 1.4 ml of chloroacetyl chloride in 10 ml of dichloromethane and then stirred at ambient temperature for four hours. The mixture was diluted with 100 ml of ethyl acetate, dried over anhydrous magnesium sulfate, filtered and evaporated to yield 5.0 g of 1-(2-chloroacetyl)-4-(2,3,4,5,6-pentafluorophenoxy)-4-phenylpiperidine as an oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04853384 |
| 出典データセット | uspto-grants-1989_08 |
| ORD ID | ord-0bb438774a1942aebe53a34a253b8c70 |
| 出典メモ | uspto-grants-1989_08 |