Diethyl Ether → HCID 178484253, compound

Participants

Reaction Steps

Dimethylformamide dimethyl acetal (304 mL, 2.28M) was added to a suspension of 2-amino-4-hydroxy-N-(1,1-dimethylethyl)-5-pyrimidinesulfonamide (304 g, 1.23M) in DMF (3000 mL). Stirring was continued for 1/2 hour after precipitate formation and then the reaction slurry was concentrated in vacuo. Trituration of the resulting white solid with ether afforded the desired compound (362 g, yield 97%, m.p. 258°-261° C.). The compound was dried in vacuo at 40° C. for 16 hours.

Provenance & Evidence