4-(4-Fluorobenzoyl)piperidine → HCID 70395401, compound

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Reaction Steps

A mixture of 8.4 g of 2,6-dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid methyl ester 2-chloroethyl ester and 8.8 g of 4-(p-fluorobenzoyl)-piperidine is stirred under argon for 1 hour at a temperature of 145°. After working up, the resulting residue is chromatographed over 500 g of silica gel, yielding 2,6-dimethyl-4-(2,3-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid methyl ester 2-[4-(p-fluorobenzoyl)-piperidino]-ethyl ester in amorphous form which exhibits the following characteristic bands in th NMR spectrum: 1H-NMR (CDCl3): 2.3 and 2.4 [2S, 6H, 2 H3C--C (2 and 6)]; 3.6 [s, 3H, H3C--OOC]; 5.4 [s, 1H, H-c (4)], 7.1-8.1 (m, 7H, 7 arom. H). Rf value: 0.40 (hexane/ethyl acetate/methanol=4:2:1).

Provenance & Evidence