Ethyl bromoacetate → alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcohol

HRID 1721927Notes

Reaction equation

[CH2:1]([O:3][CH2:4][N:5]1[C:9]([CH:10]([OH:20])[C:11]2[CH:16]=[CH:15][C:14]([OH:17])=[C:13]([Cl:18])[C:12]=2[Cl:19])=[CH:8][CH:7]=[N:6]1)[CH3:2].Br[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>>[CH2:1]([O:3][CH2:4][N:5]1[C:9]([CH:10]([OH:20])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[C:13]([Cl:18])[C:12]=2[Cl:19])=[CH:8][CH:7]=[N:6]1)[CH3:2]

Participants

Reactant 2

HCID 7748Ethyl bromoacetate

HCID 14622794alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-hydroxybenzylalcohol

Product 1

HCID 20030167alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcoholYield 98%

Procedure

634 mg of α-(1-ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-hydroxybenzylalcohol and 367 mg of ethyl bromoacetate are treated in the same manner as described in Example 1 to give 790 mg of α-(1-ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-ethoxycarbonylmethoxybenzylalcohol.

Sources & evidence

ORD record: ord-d72d35cb89a64b19b546944f583191ce
Source dataset: uspto-grants-1989_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04853404

Reaction notes

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