Sodium Hydroxide → [2,3-Dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetic acid

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Reaction Steps

0.9 g of ethyl [2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetate is suspended in 20 ml of ethanol, and 10 ml of an aqueous 10% sodium hydroxide solution are added thereto. The mixture is stirred at room temperature for 1 hour. The reaction mixture is concentrated to remove ethanol and adjusted to pH 1-2 with 10% hydrochloric acid. The resulting crystals are collected by filtration, washed successively with water and isopropyl ether, and dried to give 0.82 g of [2,3-dichloro-4-(1-ethoxymethyl-5-pyrazolylcarbonyl)phenoxy]acetic acid.

Provenance & Evidence