alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-methoxy-benzylalcohol → HCID 14622785, compound

HRID 1721936Notes

Reaction equation

HRID 1721936 reaction equation
[CH2:1]([O:3][CH2:4][N:5]1[C:9]([CH:10]([OH:21])[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([Cl:19])[C:12]=2[Cl:20])=[CH:8][CH:7]=[N:6]1)[CH3:2]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:20][C:12]1[C:13]([Cl:19])=[C:14]([O:17][CH3:18])[CH:15]=[CH:16][C:11]=1[C:10]([C:9]1[N:5]([CH2:4][O:3][CH2:1][CH3:2])[N:6]=[CH:7][CH:8]=1)=[O:21]

Participants

4

Reactant 1

HCID 14622784alpha-(1-Ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-methoxy-benzylalcohol

Product 1

HCID 14622785HCID 14622785, compoundYield 90%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

2.72 g of manganese dioxide are added to a solution of 1.04 g of α-(1-ethoxymethyl-5-pyrazolyl)-2,3-dichloro-4-methoxybenzylalcohol in methylene chloride and the mixture is stirred at room temperature for 27 hours. The reaction mixture is filtered and the filtrate is condensed to an oily residue, which is then crystallized from isopropyl ether to give 0.93 g of (2,3-dichloro-4-methoxyphenyl)(1-ethoxymethyl-5-pyrazolyl)methanone.

Workup

  1. filtrationThe reaction mixture is filtered
  2. customcondensed to an oily residue, which
  3. customis then crystallized from isopropyl ether

Sources & evidence

ORD record
ord-4c141264c8fb4744bc6d536ffdaf317e
Source dataset
uspto-grants-1989_08
Patent number
US04853404

Reaction notes

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