反应详情

A solution of 5.51 g of boron tribromide in methylene chloride is added dropwise to a solution of 2.05 g of 2,3-dichloro-4-methoxybenzaldehyde in methylene chloride. The mixture is stirred at room temperature for 4 hours, poured into ice-water and then extracted with ethyl acetate. The extract is washed with water, dried and evaporated to remove solvent. 10% hydrochloric acid and methanol are added to the residue and the mixture is stirred for 3 hours under ice-cooling and extracted with ethyl acetate again. The extract is washed with water, dried and evaporated to remove solvent. The residue is crystallized with isopropyl ether to give 1.82 g of 4-hydroxy-2,3-dichlorobenzaldehyde.

1. extractionextracted with ethyl acetate
2. washThe extract is washed with water
3. customdried
4. customevaporated
5. customto remove solvent
6. addition10% hydrochloric acid and methanol are added to the residue
7. stirringthe mixture is stirred for 3 hours under ice-
8. temperaturecooling
9. extractionextracted with ethyl acetate again
10. washThe extract is washed with water
11. customdried
12. customevaporated
13. customto remove solvent
14. customThe residue is crystallized with isopropyl ether