Ammonia → HCID 13691208, compound

Participants

Reaction Steps

A solution of 3.38 g of the product of Example 6 and 25 ml of tetrahydrofuran was added at -78° C. to 30 ml of ammonia and after adding 3 g of sodiunm at -40° C., the mixture was stirred for 90 minutes under an inert atmosphere. 24 g of ammonium chloride were added at -40° C. and the ammonia evaporated. The residue was diluted with water and the mixture was extracted with ethyl acetate. The organic phase was washed with water, aqueous sodium chloride, dried over a deshydrant, filtered and evaporated to dryness to obtain 2.86 g of N-[3-{2-(3-[1H-indol-4-yl]-propyl)-phenoxy}-propyl]2-methyl-2-propanamine.

Provenance & Evidence