反应详情

A mixture of 100 mg of 4-hydroxy-acetophenone, 96 mg of n-tetrabutylammonium acid sulfate, 1.5 ml of 50% sodium hydroxide solution, 3 ml of benzene, 1.5 ml of acetonitrile and 0.2 ml of 2-chloroethyl p-toluene sulfonate was refluxed for 18 hours under an inert atmosphere and the decanted phase was extracted with benzene. The organic phase was washed with water, dried over a deshydrant and evaporated to dryness under reduced pressure. The residue was chromatographed over silica and eluted with dichloroethane to obtain 127 mg of 1-[4-(2-chloroethoxy)-phenyl]-ethanone melting at ≃62° C.

1. temperaturewas refluxed for 18 hours under an inert atmosphere
2. extractionthe decanted phase was extracted with benzene
3. washThe organic phase was washed with water
4. customdried over a deshydrant
5. customevaporated to dryness under reduced pressure
6. customThe residue was chromatographed over silica
7. washeluted with dichloroethane