HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 19862725, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1-(4-iodophenyl)pyrrolidine | HCID 11277307 | — |
| Reactant | 1-Bromo-4-[(prop-2-yn-1-yl)oxy]butane | HCID 19862686 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | HCID 19862725 | HCID 19862725 | 10.7% |
Reaction Steps
A mixture of 1-(4-iodophenyl)pyrrolidine (22.8 g), the product of stage (i) (16.0 g), BTPC (1.5 g) and copper (I) iodide (150 mg) in DEA (125 ml) and THF (125 ml) was stirred under nitrogen for 18 h. The dark mixture was treated with ether (250 ml), the precipitate was removed by filtration and the filtrate was concentrated to a black oil which was purified by FCC (hexane→System D 9:1) to give the title compound as a pale yellow oil (3.0 g) T.l.c. (System D 9:1) Rf 0.24.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04853381 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-d4e004abed024b77b4f9310887391b76 |
| Source note | uspto-grants-1989_08 |