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Calcium Carbonate → 6-[3-[4-(1-Pyrrolidinyl)phenyl]propoxy]-2-hexanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Calcium Carbonate | HCID 10112 | — |
| 反応物 | 1-[4-[3-[4-(2-Methyl-1,3-dithian-2-yl)butoxy]propyl]phenyl]pyrrolidine | HCID 19862733 | — |
| 触媒 | Mercuric Chloride | HCID 24085 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | 6-[3-[4-(1-Pyrrolidinyl)phenyl]propoxy]-2-hexanone | HCID 19862701 | — |
反応手順
A solution of the product of stage (iv) (3.2 g) in THF (50 ml) was added to a stirred suspension of mercury (II) chloride (8.5 g) and calcium carbonate (3.2 g) in methanol-water (9:1, 50 ml) and the mixture was stirred at reflux for 1 h. The reaction was filtered through hyflo, the filtrate was concentrated in vacuo and the resulting oil was dissolved in chloroform (50 ml). The resulting precipitate was removed by filtration, the solvent was evaporated and the residue was purified by FCC (System D 19:1→4:1) to give the title compound as a crystalline mass (1.4 g) m.p. 30°-31°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04853381 |
| 出典データセット | uspto-grants-1989_08 |
| ORD ID | ord-5f2ef6d99d184d2296edef7dfc469a1a |
| 出典メモ | uspto-grants-1989_08 |