HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1721971Generated: October 25, 2026
Epichlorohydrin → 2-Methyl-4-(2,3-epoxypropoxy)benzaldehyde
https://huagongshe.com/reaction/1721971
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | 4-Hydroxy-2-methylbenzaldehyde | HCID 458185 | — |
| Reactant | 2-Methyl-4-(2,3-epoxypropyl)benzaldehyde | HCID 20029917 | — |
| Solvent | Sodium Hydroxide | HCID 14798 | — |
| Product | 2-Methyl-4-(2,3-epoxypropoxy)benzaldehyde | HCID 13302065 | — |
Reaction Steps
To epichlorohydrin (20 g., 0.216 mole) heated at 55° C. is added dropwise a solution of 2-methyl-4-hydroxybenzaldehyde (9.0 g., 0.006 mole) in 2.5 N sodium hydroxide solution (40 ml.). After the addition, the solution is allowed to stir an additional 3 hours at 55° C. and then at room temperature overnight. the oil is distilled to give 8.3 g. of 2-methyl-4-(2,3-epoxypropyl)benzaldehyde, m.p. 160°-170° C. at 1 mm. Hg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04853383 |
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| Source dataset | uspto-grants-1989_08 |
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| ORD ID | ord-ca0230d404b140aeafd5657131abbb71 |
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| Source note | uspto-grants-1989_08 |
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