Epichlorohydrin → HCID 20029869, compound

HRID 1721978Notes

Reaction equation

HRID 1721978 reaction equation
[Cl:1][C:2]1[CH:9]=[C:8]([OH:10])[CH:7]=[C:6]([Cl:11])[C:3]=1[CH:4]=[O:5].[CH2:12]([CH:14]1[O:16][CH2:15]1)Cl>[OH-].[Na+]>[Cl:1][C:2]1[CH:9]=[C:8]([O:10][CH2:12][CH:14]2[O:16][CH2:15]2)[CH:7]=[C:6]([Cl:11])[C:3]=1[CH:4]=[O:5]

Participants

4

Reactant 2

HCID 7835EpichlorohydrinHCID 5283822,6-Dichloro-4-hydroxybenzaldehyde

Product 1

HCID 20029869HCID 20029869, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

To a stirred solution of 2,6-dichloro-4-hydroxybenzaldehyde (3.0 gm 0.0167 m) in 1.5N sodium hydroxide (25 m) at 50° is added epichlorohydrin (4.4 gm, 0.048 m). After stirring at 50° for 3 hours, the solution is cooled and extracted with chloroform. The chloroform is dried over anhydrous sodium sulfate, filtered and concentrated to 2,6-dichloro4-(2,3-epoxypropoxy)-benzaldehyde (3 g) which is used without further purification.

Workup

  1. temperaturethe solution is cooled
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform is dried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated to 2,6-dichloro4-(2,3-epoxypropoxy)-benzaldehyde (3 g) which
  6. customis used without further purification

Sources & evidence

ORD record
ord-96cb687ec13240d88d6123af9db4cb0c
Source dataset
uspto-grants-1989_08
Patent number
US04853383

Reaction notes

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