Isopropanol → HCID 13560818, compound

Participants

Reaction Steps

To a solution of β-(3,4-dimethoxyphenyl)ethylamine (151.0 g, 0.83 m) in isopropanol (160 ml) heated at 50° is added a solution of glycidol (24.8 g, 0.33 m) in isopropanol (25 ml) over 30 minutes. After heating at 50° for 30 minutes and at 70° for 15 hours, the solvent is concentrated under reduced pressure. The residue is distilled at 224°-227° C. at 0.7 mm to yield I (47.9 g, 57%).

Provenance & Evidence