Acetic Acid → HCID 178467481, compound

Participants

Reaction Steps

A solution of 45 (1.0 g, 0.004 mol), glacial acetic acid (5.33 ml) and 48% HBr (22 ml) was heated at reflux for 3 hours with stirring. The reaction was cooled in an ice bath and the yellow precipitate was collected and combined with the residue resulting from concentration of the mother liquor. The solid was suspended in H2O (15 ml) and saturated NaHCO3 solution (41 ml) and stirred at ambient temperature overnight. The solids were collected, washed with H2O, and dried to yield 850 mg (98.4%) of 46; m.p. 300° C.

Provenance & Evidence