Bromine → HCID 178488960, compound

Participants

Reaction Steps

To a suspension of 55 (2.56 g, 0.0092 mol) in CHCl3 (75ml) was added dropwise with stirring a solution of bromine (1.55 g, 0.0096 mol) in CHCl3 (75 ml). After stirring for 3 days, saturated NaHCO3 was added, the layers separated and the aqueous layer extracted with CHCl3 (2 x). The organic extracts were dried, filtered and concentrated to dryness. The residue was chromatographed on silica gel and the product eluted with 1.5% CH3OH-CHCl3 to yield 2.25 g (69%) of 56, m.p. 228.30° C. (CHCl3). Analysis calculated for C11H7BrClF3N2O.

Provenance & Evidence