4-Pyridineethanamine → HCID 178526948, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-{p-[4-(2-thienyl)-2-imidazolyl]phenoxy}-1,2-epoxypropane (5.0 g, 0.017 m) and 4-(2-aminoethyl)pyridine (3.18 g, 0.026 m) in isopropanol (90 ml) was stirred at 70° C. for 23 hours. The solvent was evaporated under reduced pressure and the residue chromatographed on silica gel and eluted with 5% MeOH-CHCl3 saturated with NH3, and then rechromatographed eluting with 10% MeOH-CHCl3 saturated with NH3. Compound 78 was isolated as an amorphous solid.

Provenance & Evidence