Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzaldehyde → [2-Phenyl-3-(4-phenylbutan-2-yl)-1,3-oxazolidin-5-yl]methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzaldehyde | HCID 240 | — |
| 반응물 | Benzoic Acid | HCID 243 | — |
| 반응물 | 3-(1-Phenyl-3-butyl)amino-1,2-propanediol | HCID 5195560 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | [2-Phenyl-3-(4-phenylbutan-2-yl)-1,3-oxazolidin-5-yl]methanol | HCID 53876813 | 100% |
반응 단계
A solution of 94 (24 g, 0.108 mol), toluene, benzaldehyde (40 ml) and benzoic acid (0.5 g) was heated at reflux with a Dean-Stark trap. After 1 hour, the theoretical amount of H2O was collected, the reaction cooled to room temperature and saturated Na2CO3 added. The aqueous layer was separated and washed with CHCl3 (3X). The combined extracts were dried, filtered and concentrated to dryness to yield 34 g (100%) of 95.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04853383 |
| 출처 데이터셋 | uspto-grants-1989_08 |
| ORD ID | ord-e6ffced05b2046e69b4f02e0ca263b05 |
| 출처 메모 | uspto-grants-1989_08 |