HCID 20030226, compound → HCID 53777539, compound

HRID 1722034Notes

Reaction equation

HRID 1722034 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[CH3:7][O:8][C:9]1[C:18]([F:19])=[CH:17][C:16]([F:20])=[C:15]([F:21])[C:10]=1[C:11](OC)=[O:12]>C(OCC)C>[CH3:7][O:8][C:9]1[C:18]([F:19])=[CH:17][C:16]([F:20])=[C:15]([F:21])[C:10]=1[CH2:11][OH:12]

Participants

4

Reactant 2

HCID 20030226HCID 20030226, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 53777539HCID 53777539, compoundYield 92.5%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Lithium aluminium hydride (1.5 g) was added in portions to a stirred mixture of methyl 2-methoxy-3,5,6-trifluorobenzoate (10.9 g) in dry diethyl ether (80 cm3) over a period of 30 minutes at the ambient temperature and the resultant mixture stirred for a further period of 30 minutes. The product, 2-methoxy-3,5,6-trifluorobenzyl alcohol (8.8 g), was isolated by a similar procedure to that illustrated in Example 6.

Sources & evidence

ORD record
ord-1555ae827b23477f8d7558cec145b834
Source dataset
uspto-grants-1989_08
Patent number
US04853414

Reaction notes

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