Trifluoroacetic acid → HCID 20030211, compound

Participants

Reaction Steps

A solution of 4.62 g of crude product of the preceding Preparation, 4-(3,4-dichloro-6-hydroxyphenyl)-1,1,1-trifluoro-butan-2,4-dione (about 40% by NMR) and 4.6 ml trifluoroacetic acid in 27.6 ml methylene chloride was heated at reflux for 8 hours, then allowed to stand at 23° C. for 16 hours. The reaction was washed with 3×25 ml 1N sodium hydroxide and 25 ml brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to give 2.0 g (86%) of product; m.p. 98°-101° C.

Provenance & Evidence