反应详情

A solution of 3.0 g of 3-(1-methyl-4-piperidinyl)-1H-indazole in 15 ml of 4-fluorobenzoyl chloride was heated at 100° for 2 hrs. The reaction mixture was poured into ether and the precipitate was collected. The precipitate was treated with dilute aqueous sodium hydroxide solution and extracted with chloroform. The chloroform extract was dried over anhydrous magnesium sulfate and the solvent removed in vacuo to yield 2.5 g (53%) of product, mp 132°-133° C.

1. customthe precipitate was collected
2. additionThe precipitate was treated with dilute aqueous sodium hydroxide solution
3. extractionextracted with chloroform
4. extractionThe chloroform extract
5. dry with materialwas dried over anhydrous magnesium sulfate
6. customthe solvent removed in vacuo