Ethanol → Lesinurad

HRID 172212Notes

Reaction equation

HRID 172212 reaction equation
[Br:3][c:4]1[n:5](-[c:25]2[cH:26][cH:27][c:28]([CH:35]3[CH2:36][CH2:37]3)[c:29]3[cH:30][cH:31][cH:32][cH:33][c:34]23)[c:6]([S:9][CH2:10][C:11](=[O:12])[NH:13][c:14]2[cH:15][cH:16][c:17]([S:18](=[O:19])(=[O:20])[NH2:21])[cH:22][c:23]2[Cl:24])[n:7][n:8]1.[CH3:38][CH2:39][OH:40].[Na+:2].[OH-:1]>>[OH:1][C:11]([CH2:10][S:9][c:6]1[n:5](-[c:25]2[cH:26][cH:27][c:28]([CH:35]3[CH2:36][CH2:37]3)[c:29]3[cH:30][cH:31][cH:32][cH:33][c:34]23)[c:4]([Br:3])[n:8][n:7]1)=[O:12]

Participants

5

Reactant 4

HCID 702EthanolHCID 923Sodium ionHCID 961HydroxideHCID 115199512-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)-N-(2-chloro-4-sulfamoylphenyl)acetamide

Product 1

HCID 53465279Lesinurad

Sources & evidence

ORD record
ord-8412c3dfd22940d3abd2077fcee56523
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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