HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 2-(1-Naphthylmethylene)-3-(morpholinocarbonyl)propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 3-[(Naphthalen-1-yl)methylidene]oxolane-2,5-dione | HCID 54316428 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(1-Naphthylmethylene)-3-(morpholinocarbonyl)propionic acid | HCID 54534320 | 80.5% |
Reaction Steps
A solution of 1.00 g of 2-(1-naphthylmethylene)succinic anhydride and 0.37 g of morpholine in 31 ml of dry dichloromethane was stirred for 2 hours. The reaction mixture was evaporated under reduced pressure, and the residue was crystallized from a mixture of ethyl acetate, benzene and hexane (1:1:1) to obtain 1.10 g of 2-(1-naphthylmethylene)-3-(morpholinocarbonyl)propionic acid as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04853463 |
| Source dataset | uspto-grants-1989_08 |
| ORD ID | ord-7a359e0fb72348c3aaae380189936439 |
| Source note | uspto-grants-1989_08 |