HCID 53811135, compound → HCID 15596444, compound

Participants

Reaction Steps

N-Isobutyl-7-phenylhept-2-en-6-ynamide (100 mg) and 5% Pd/BaSO4 (17 ml) in dry methanol (3 ml) at 20° C. was treated with hydrogen until hydrogen uptake was 85% of theoretical. The mixture was diluted with methanol, filtered and the solvent was removed from the filtrate. The residue was treated with ether and the solvent removed in a stream of nitrogen. The product was purified by chromatography on silica (15 g), eluting with 1:1 ether:hexane grading to 100% ether to give N-isobutyl-7-phenylhepta-2E,6Z-dienamide (61 mg) as a yellow oil which crystallised on standing mp 42°-5° C.

Provenance & Evidence