Methylamine → HCID 22164809, compound

Participants

Reaction Steps

Boron trifluoride etherate (5 ml) was added cautiously to a mixture of ethyl 7-chloro-1-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate (5 g) and a solution of methylamine in IMS (32%; 35 ml) and the mixture was boiled under reflux for 8 hours. The same quantities of boron trifluoride etherate and methylamine in IMS were added and the mixture was boiled under reflux for 24 hours. The same quantities of boron trifluoride etherate and methylamine in IMS were added and the mixture was boiled under reflux for 8 hours. The mixture was kept at ambient temperature for 16 hours and then filtered. The residue was washed with IMS, dried and recrystallised from aqueous IMS to give the novel compound 7-chloro-1,N-dimethyl-4-oxo-1,4-dihydroquinoline-3-carboxamide, m.p. 260°-263°.

Provenance & Evidence