HCID 178418361, compound → HCID 13799208, compound

Participants

Reaction Steps

0.7 g of 5-hydroxy-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester is hydrogenated in 50 ml of ethanol with 0.5 g of Raney nickel at a hydrogen pressure of 80 bars and a temperature of 100° C. for 6 hours. After filtering off of the catalyst, the solvent is evaporated in a vacuum. The residue is chromatographed on silica gel with dichloromethane and ethanol=10+1. 0.108 g of 4-methoxymethyl-5-oxo-5,6,7,8-tetrahydro-beta-carboline-3-carboxylic acid ethyl ester with a melting point of 249°-250° C. is obtained.

Provenance & Evidence