Thiophenol → HCID 178449601, compound

HRID 1722263Notes

Reaction equation

HRID 1722263 reaction equation
[NH2:1][C@:2]([C:6]([NH:8][C@H:9]([C:17]([NH:19][C@H:20]([C:39]([OH:41])=[O:40])[CH2:21][C:22]1[N:26]=[CH:25][N:24](C2C=CC([N+]([O-])=O)=CC=2[N+]([O-])=O)[CH:23]=1)=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:7])([CH2:4][CH3:5])[CH3:3].[CH:42]1([CH2:48][C@H:49]([NH-:59])[CH:50]([OH:58])[CH2:51][C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][N:53]=2)[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]1.C1(S)C=CC=CC=1>>[NH2:1][C@:2]([C:6]([NH:8][C@H:9]([C:17]([NH:19][C@H:20]([C:39]([OH:41])=[O:40])[CH2:21][C:22]1[N:26]=[CH:25][NH:24][CH:23]=1)=[O:18])[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:7])([CH2:4][CH3:5])[CH3:3].[CH:42]1([CH2:48][C@H:49]([NH-:59])[CH:50]([OH:58])[CH2:51][C:52]2[CH:57]=[CH:56][CH:55]=[CH:54][N:53]=2)[CH2:47][CH2:46][CH2:45][CH2:44][CH2:43]1

Participants

3

Reactant 2

HCID 7969ThiophenolHCID 131716024HCID 131716024, compound

Product 1

HCID 178449601HCID 178449601, compound

Procedure

380 mg of Iva-Phe-His(DNP)-1(S)-cyclohexylmethyl-2(R,S)-hydroxy-3-(2-pyridyl)propylamide are reacted with thiophenol to give the title compound in analogy to reference example 1(a).

Sources & evidence

ORD record
ord-b17eae29d6e549c68f48e9263ed4617e
Source dataset
uspto-grants-1989_08
Patent number
US04855286

Reaction notes

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